Reaction Details |
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Target | N-lysine methyltransferase SMYD2 |
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Ligand | BDBM378760 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SMYD2 Biochemical Assay |
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IC50 | 14.0±n/a nM |
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Citation | Foley, MA; Kuntz, KW; Mills, JE; Mitchell, LH; Munchhof, MJ; Harvey, DM Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer US Patent US10266526 Publication Date 4/23/2019 |
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More Info.: | Get all data from this article, Assay Method |
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N-lysine methyltransferase SMYD2 |
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Name: | N-lysine methyltransferase SMYD2 |
Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 49689.57 |
Organism: | Homo sapiens (Human) |
Description: | Q9NRG4 |
Residue: | 433 |
Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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BDBM378760 |
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n/a |
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Name | BDBM378760 |
Synonyms: | 1-cyclopropyl-N-(1-((1-(4-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)methyl)azetidin-3-yl)-1H-1,2,3-triazole-4-carboxamide | US10266526, Compound 943 |
Type | Small organic molecule |
Emp. Form. | C21H22F3N7O |
Mol. Mass. | 445.4409 |
SMILES | FC(F)(F)c1ccc(Cn2cc(CN3CC(C3)NC(=O)c3cn(nn3)C3CC3)cn2)cc1 |
Structure |
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