| Reaction Details |
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 | Report a problem with these data |
| Target | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
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| Ligand | BDBM13139 |
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| Substrate/Competitor | Fluorescent peptide WAAG-3R |
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| Meas. Tech. | Aggrecanase-1 Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 303.15±n/a K |
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| Comments | Not active uM. |
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| Citation |  Xiang, JS; Hu, Y; Rush, TS; Thomason, JR; Ipek, M; Sum, PE; Abrous, L; Sabatini, JJ; Georgiadis, K; Reifenberg, E; Majumdar, M; Morris, EA; Tam, S Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors. Bioorg Med Chem Lett16:311-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| A disintegrin and metalloproteinase with thrombospondin motifs 4 |
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| Name: | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
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| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) | ADAMTS4 | ATS4_HUMAN | Aggrecanase-1 | KIAA0688 | Metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) |
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| Type: | Enzyme |
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| Mol. Mass.: | 90214.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75173 |
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| Residue: | 837 |
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| Sequence: | MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEE
IVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLG
GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHI
LRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR
YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN
TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA
HELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY
GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA
MCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV
QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSF
PGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHA
GCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNP
GHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQP
LTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
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| BDBM13139 |
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| Fluorescent peptide WAAG-3R |
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| Name: | Fluorescent peptide WAAG-3R |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 1954.08 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 19 |
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| Sequence: | Abz-TEGEARGSVI-Dap(Dnp)-KK
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