| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM261736 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | M1 PAM Assay |
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| EC50 | 41.0±n/a nM |
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| Citation |  Groebke Zbinden, K; Pinard, E; Ryckmans, T Flouro-naphthyl derivatives US Patent US9708302 Publication Date 7/18/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM261736 |
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| n/a |
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| Name | BDBM261736 |
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| Synonyms: | 1-fluoro-N- ((1SR,2RS)-2- hydroxy-2- methylcyclohexyl)- 4-((6-(1-methyl-1H- pyrazol-4-yl)pyridin- 3-yl)methyl)-2- naphthamide | US9708302, 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29FN4O2 |
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| Mol. Mass. | 472.5539 |
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| SMILES | Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCCC[C@@]3(C)O)c(F)c3ccccc23)cn1 |r| |
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| Structure | 
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