| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Rho-associated protein kinase 2 |
|---|
| Ligand | BDBM380206 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Glunz, PW; Zou, Y; Quan, ML; Ladziata, V Phthalazinones and isoquinolinones as rock inhibitors US Patent US9926282 Publication Date 3/27/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Rho-associated protein kinase 2 |
|---|
| Name: | Rho-associated protein kinase 2 |
|---|
| Synonyms: | KIAA0619 | ROCK-II | ROCK2 | ROCK2_HUMAN | Rho kinase 2 (ROCKII) | Rho-associated protein kinase 2 (ROCK-2) | Rho-associated protein kinase 2 (ROCK2) | Rho-associated protein kinase 2 (ROCKII) | Rho-associated protein kinase 2/Transforming protein RhoA | Rho-associated, coiled-coil-containing protein kinase 2 | Rho-associated, coiled-coil-containing protein kinase II | Serine/threonine-protein kinase RIO2 | p164 ROCK-2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 160885.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75116 |
|---|
| Residue: | 1388 |
|---|
| Sequence: | MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR
DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKI
LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK
IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLK
QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMN
LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK
KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE
LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQF
EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQ
MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPG
DAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL
DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKG
HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD
ISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR
QLAPNKPS
|
|
|
|---|
| BDBM380206 |
|---|
| n/a |
|---|
| Name | BDBM380206 |
|---|
| Synonyms: | 5-(adamantan-1-yl)-1- methyl-N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1H-pyrazole- 3-carboxamide | US9926282, Example 201 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H29N5O2 |
|---|
| Mol. Mass. | 479.5729 |
|---|
| SMILES | Cn1nc(cc1C12CC3CC(CC(C3)C1)C2)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 |TLB:13:8:15:12.14.11,13:12:15:9.8.7,THB:7:6:9.8.13:11,7:8:6.15.14:11,5:6:9.8.13:11| |
|---|
| Structure | 
|
|---|
Search and Browse
