| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
|---|
| Ligand | BDBM291201 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| IC50 | 550±n/a nM |
|---|
| Citation |  Sun, Y; Feng, H; Li, Y; Mei, S; Pan, J; Wang, A; Ye, H; Zhang, K Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors US Patent US9890162 Publication Date 2/13/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase pim-2 |
|---|
| Name: | Serine/threonine-protein kinase pim-2 |
|---|
| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 34185.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9P1W9 |
|---|
| Residue: | 311 |
|---|
| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
|
|
|
|---|
| BDBM291201 |
|---|
| n/a |
|---|
| Name | BDBM291201 |
|---|
| Synonyms: | N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-pyridin-4-ylpiperidin-1-yl)quinoline-2-carboxamide | US9580418, Example 21 | US9890162, Example 21 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H35N7O |
|---|
| Mol. Mass. | 521.6559 |
|---|
| SMILES | C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NC(=O)c1ccc2ccc(cc2n1)N1CCC(CC1)c1ccncc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
