| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G-protein coupled receptor 6 |
|---|
| Ligand | BDBM382110 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | A.1 Inhibition of cAMP Activity of GPR6 In Vitro Assay |
|---|
| EC50 | 6800±n/a nM |
|---|
| Citation |  Adams, ME; Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Lam, B; Monenschein, H; Reichard, H; Sun, H Pyrazines as modulators of GPR6 US Patent US10273225 Publication Date 4/30/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G-protein coupled receptor 6 |
|---|
| Name: | G-protein coupled receptor 6 |
|---|
| Synonyms: | G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37886.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P46095 |
|---|
| Residue: | 362 |
|---|
| Sequence: | MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
|
|
|
|---|
| BDBM382110 |
|---|
| n/a |
|---|
| Name | BDBM382110 |
|---|
| Synonyms: | US10000468, Example 18 | US10273225, Example 18 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H34F3N7O |
|---|
| Mol. Mass. | 517.5897 |
|---|
| SMILES | CC(C)Nc1nc(C(=O)N(C)CCN(C)C)c(nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
