| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 3 |
|---|
| Ligand | BDBM25174 |
|---|
| Substrate/Competitor | BDBM25143 |
|---|
| Meas. Tech. | HDAC Activity Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| Comments | extracted |
|---|
| Citation |  Jones, P; Bottomley, MJ; Carfí, A; Cecchetti, O; Ferrigno, F; Lo Surdo, P; Ontoria, JM; Rowley, M; Scarpelli, R; Schultz-Fademrecht, C; Steinkühler, C 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors. Bioorg Med Chem Lett18:3456-61 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Histone deacetylase 3 |
|---|
| Name: | Histone deacetylase 3 |
|---|
| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48829.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15379 |
|---|
| Residue: | 428 |
|---|
| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
|
|
|
|---|
| BDBM25174 |
|---|
| BDBM25143 |
|---|
| Name | BDBM25174 |
|---|
| Synonyms: | 1-[(5-methanesulfonylthiophen-2-yl)carbonyl]-2,3-dihydro-1H-indole | thiophene derivative, 17h |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H13NO3S2 |
|---|
| Mol. Mass. | 307.388 |
|---|
| SMILES | CS(=O)(=O)c1ccc(s1)C(=O)N1CCc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
