Reaction Details |
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Target | ATP phosphoribosyltransferase |
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Ligand | BDBM25318 |
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Substrate/Competitor | BDBM25315 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 8.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 10000±n/a nM |
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Comments | 50% inhibition @ 10 uM. |
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Citation | Cho, Y; Ioerger, TR; Sacchettini, JC Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem51:5984-92 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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ATP phosphoribosyltransferase |
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Name: | ATP phosphoribosyltransferase |
Synonyms: | ATP-PRT | ATP-PRTase | HIS1_MYCTU | hisG |
Type: | Glycosyltransferase |
Mol. Mass.: | 30473.85 |
Organism: | Mycobacterium tuberculosis |
Description: | n/a |
Residue: | 284 |
Sequence: | MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSG
ELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLV
RKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLSQHDLVAFGEPLCDSEAV
LIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIA
PLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
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BDBM25318 |
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BDBM25315 |
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Name | BDBM25318 |
Synonyms: | (4-methoxyphenyl)methyl 2-methyl-5-oxo-4,7-bis(thiophen-2-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | ChemBridge hexahydroquinoline-3-carboxylate, 10 |
Type | n/a |
Emp. Form. | C27H25NO4S2 |
Mol. Mass. | 491.622 |
SMILES | COc1ccc(COC(=O)C2=C(C)N=C3CC(CC(=O)C3C2c2cccs2)c2cccs2)cc1 |c:10,t:13| |
Structure |
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