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TargetBcl-2-like protein 1
LigandBDBM25525
Substrate/CompetitorBak-BH3 peptide
Meas. Tech.Fluorescence Polarization Assay
pH8±n/a
Temperature295.15±n/a K
IC50 19000±n/a nM
Citation Bernardo, PH; Wan, KF; Sivaraman, T; Xu, J; Moore, FK; Hung, AW; Mok, HY; Yu, VC; Chai, CL Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors. J Med Chem51:6699-710 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM25525
Bak-BH3 peptide
Name:Bak-BH3 peptide
Synonyms:F-BakBH3
Type:Fluorescein-labeled peptide
Mol. Mass.:1724.92
Organism:n/a
Description:Derived from human apoptosis regulator BAK (residues 72-87).
Residue:16
Sequence:
GQVGRQLAIIGDDINR