| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase TXK |
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| Ligand | BDBM384533 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity In Vitro Assays |
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| IC50 | 1.50±n/a nM |
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| Citation |  Owens, T; Hill, RJ Benzimidazole derivatives as RLK and ITK inhibitors US Patent US9932329 Publication Date 4/3/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase TXK |
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| Name: | Tyrosine-protein kinase TXK |
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| Synonyms: | PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK) |
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| Type: | Protein |
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| Mol. Mass.: | 61268.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42681 |
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| Residue: | 527 |
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| Sequence: | MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
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| BDBM384533 |
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| n/a |
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| Name | BDBM384533 |
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| Synonyms: | N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyrrolidin-2-yl)methyl)-5-((((S)-1-hydroxy-3,3-dimethylbutan-2-yl)amino)methyl)-1H-benzo[d]imidazol-2-yl)-5-(oxazol-5-yl)thiophene-2-carboxamide formate | US9932329, Cpd # 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H43N7O4S |
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| Mol. Mass. | 657.825 |
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| SMILES | CC(C)(C)C=C(C#N)C(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(s2)-c2cnco2)nc2cc(CN[C@H](CO)C(C)(C)C)ccc12 |r,w:4.3| |
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| Structure | 
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