| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proto-oncogene Wnt-1 |
|---|
| Ligand | BDBM384701 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | The screening assay for Wnt activity |
|---|
| EC50 | 1350±n/a nM |
|---|
| Citation |  KC, SK; Wallace, DM; Cao, J; Chiruta, C; Hood, J 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof US Patent US10285982 Publication Date 5/14/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proto-oncogene Wnt-1 |
|---|
| Name: | Proto-oncogene Wnt-1 |
|---|
| Synonyms: | INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 41006.01 |
|---|
| Organism: | Homo sapiens (human) |
|---|
| Description: | P04628 |
|---|
| Residue: | 370 |
|---|
| Sequence: | MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL
|
|
|
|---|
| BDBM384701 |
|---|
| n/a |
|---|
| Name | BDBM384701 |
|---|
| Synonyms: | US10285982, Compound 278 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H19F2N7 |
|---|
| Mol. Mass. | 431.4407 |
|---|
| SMILES | FC1(F)CCN(Cc2cncc(c2)-c2cc3c(n[nH]c3cn2)-c2cc3cccnc3[nH]2)C1 |
|---|
| Structure | 
|
|---|
Search and Browse
