| Reaction Details |
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 | Report a problem with these data |
| Target | TYR_PHOSPHATASE_2 domain-containing protein |
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| Ligand | BDBM26103 |
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| Substrate/Competitor | BDBM13466 |
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| Meas. Tech. | Determination of Inhibitor Ki |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 500±20 nM |
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| Citation |  Soellner, MB; Rawls, KA; Grundner, C; Alber, T; Ellman, JA Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB. J Am Chem Soc129:9613-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| TYR_PHOSPHATASE_2 domain-containing protein |
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| Name: | TYR_PHOSPHATASE_2 domain-containing protein |
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| Synonyms: | (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB |
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| Type: | Hydrolase |
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| Mol. Mass.: | 30152.45 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | n/a |
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| Residue: | 276 |
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| Sequence: | MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSRE
VARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSIND
AATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGL
DRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLA
AARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
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| BDBM26103 |
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| BDBM13466 |
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| Name | BDBM26103 |
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| Synonyms: | 5-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(propan-2-yl)phenyl}-1,2-oxazole-3-carboxylic acid | Isoxazole carboxylic acid, 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15F4NO3 |
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| Mol. Mass. | 393.3316 |
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| SMILES | CC(C)c1cc(ccc1-c1cc(no1)C(O)=O)-c1ccc(F)c(c1)C(F)(F)F |
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| Structure | 
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