Reaction Details |
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Target | Adenosine receptor A2 |
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Ligand | BDBM26236 |
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Substrate/Competitor | BDBM21190 |
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Meas. Tech. | Receptor Binding Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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Ki | 0.19±0.05 nM |
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Citation | Zhang X; Tellew JE; Luo Z; Moorjani M; Lin E; Lanier MC; Chen Y; Williams JP; Saunders J; Lechner SM; Markison S; Joswig T; Petroski R; Piercey J; Kargo W; Malany S; Santos M; Gross RS; Wen J; Jalali K; O'Brien Z; Stotz CE; Crespo MI; Diaz JL; Slee DH Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease. J Med Chem 51:7099-7110 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Adenosine receptor A2 |
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Name: | Adenosine receptor |
Synonyms: | A2A adenosine receptor (hA2A) | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44716.46 |
Organism: | Homo sapiens (Human) |
Description: | P29274 |
Residue: | 412 |
Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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BDBM26236 |
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BDBM21190 |
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Name | BDBM26236 |
Synonyms: | CHEMBL487569 | N-[6-(3,5-dimethoxyphenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl]acetamide | pyrazolylpyrimidine derivative, 6f |
Type | Small organic molecule |
Emp. Form. | C19H21N5O3 |
Mol. Mass. | 367.4017 |
SMILES | COc1cc(OC)cc(c1)-c1cc(NC(C)=O)nc(n1)-n1nc(C)cc1C |
Structure |
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