Ki Summary

Reaction Details

Report a problem with these data

Target

Orexin receptor type 2

Ligand

BDBM386137

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

39.0±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10287305 Publication Date 5/14/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386137

n/a

Name

BDBM386137

Synonyms:

N-((2R,3S)-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-1-((3- oxocyclobutyl)carbonyl)piperidin-3- yl)methanesulfonamide | US10287305, Example 91 | US10508083, Example 91 | US11292766, Example 91

Type

Small organic molecule

Emp. Form.

C21H36N2O5S

Mol. Mass.

428.586

SMILES

CC(C)[C@@H]1CC[C@@H](CC1)OC[C@H]1[C@H](CCCN1C(=O)C1CC(=O)C1)NS(C)(=O)=O |r,wU:3.2,6.9,11.11,12.26,(-6,3.08,;-4.67,3.85,;-4.67,5.39,;-3.33,3.08,;-3.33,1.54,;-2,.77,;-.67,1.54,;-.67,3.08,;-2,3.85,;.67,.77,;.67,-.77,;2,-1.54,;3.33,-.77,;4.67,-1.54,;4.67,-3.08,;3.33,-3.85,;2,-3.08,;.67,-3.85,;.67,-5.39,;-.67,-3.08,;-1.07,-1.59,;-2.55,-1.99,;-3.89,-1.22,;-2.15,-3.48,;3.33,.77,;4.67,1.54,;6,.77,;3.9,2.87,;5.44,2.87,)|

Structure