Ki Summary

Reaction Details

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Target

Orexin receptor type 2

Ligand

BDBM386148

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Orexin Type 2 Receptor Agonist Activity

EC50

2.30±n/a nM

Citation

Fujimoto, T; Rikimaru, K; Sugimoto, H; Matsumoto, T Substituted piperidine compound and use thereof US Patent US10287305 Publication Date 5/14/2019

More Info.:

Get all data from this article, Assay Method

Orexin receptor type 2

Name:

Orexin receptor type 2

Synonyms:

Type:

Protein

Mol. Mass.:

50710.53

Organism:

Homo sapiens (Human)

Description:

O43614

Residue:

444

Sequence:

MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW

BDBM386148

n/a

Name

BDBM386148

Synonyms:

US10287305, Example 101 | US10508083, Example 101 | US11292766, Example 101 | cis-N-isopropyl-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-3- ((methylsulfonyl)amino)piperidine-1- carboxamide

Type

Small organic molecule

Emp. Form.

C20H39N3O4S

Mol. Mass.

417.606

SMILES

CC(C)NC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)C(C)C |r,wU:22.26,19.19,16.17,10.10,(-3.33,-3.08,;-2,-3.85,;-2,-5.39,;-.67,-3.08,;.67,-3.85,;.67,-5.39,;2,-3.08,;3.33,-3.85,;4.67,-3.08,;4.67,-1.54,;3.33,-.77,;3.33,.77,;4.67,1.54,;6,.77,;3.9,2.87,;5.44,2.87,;2,-1.54,;.67,-.77,;.67,.77,;-.67,1.54,;-2,.77,;-3.33,1.54,;-3.33,3.08,;-2,3.85,;-.67,3.08,;-4.67,3.85,;-6,3.08,;-4.67,5.39,)|

Structure