Reaction Details |
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Target | Chitotriosidase-1 |
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Ligand | BDBM349923 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Human CHIT1 Activity Assay |
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IC50 | <100±n/a nM |
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Citation | Mazur, M; Koralewski, R; Borek, B; Olejniczak, S; Czestkowski, WJ; Piotrowicz, MC; Olczak, JP; Golebiowski, AA; Bartoszewicz, A; Maziarz, E; Kowalski, M Substituted amino triazoles useful as human chitinase inhibitors US Patent US9944624 Publication Date 4/17/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Chitotriosidase-1 |
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Name: | Chitotriosidase-1 |
Synonyms: | CHIT1 | CHIT1_HUMAN | Chitinase 1 | Chitinase-1 | Chitotriosidase | Chitotriosidase-1 | Chitotriosidase-1 (CHIT1) |
Type: | Enzyme |
Mol. Mass.: | 51682.25 |
Organism: | Homo sapiens (Human) |
Description: | Q13231 |
Residue: | 466 |
Sequence: | MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
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BDBM349923 |
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n/a |
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Name | BDBM349923 |
Synonyms: | 2-((2R,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)morpholin-2-yl)propan-2-ol | US10208020, Example 13 | US10538508, Example 13 | US9944624, Ex. 13 |
Type | Small organic molecule |
Emp. Form. | C21H31ClN6O2 |
Mol. Mass. | 434.963 |
SMILES | CC(C)(O)[C@H]1CN(C(Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nnc(N)[nH]1 |r| |
Structure |
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