| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
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| Ligand | BDBM19993 |
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| Substrate/Competitor | biotinylated SRC-1 peptide |
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| Meas. Tech. | HTRF Cofactor Peptide Recruitment Assay |
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| EC50 | 15±n/a nM |
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| Citation |  Kher, S; Lake, K; Sircar, I; Pannala, M; Bakir, F; Zapf, J; Xu, K; Zhang, SH; Liu, J; Morera, L; Sakurai, N; Jack, R; Cheng, JF 2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists. Bioorg Med Chem Lett17:4442-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Oxysterols receptor LXR-beta |
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| Name: | Oxysterols receptor LXR-beta |
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| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50978.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55055 |
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| Residue: | 460 |
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| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM19993 |
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| biotinylated SRC-1 peptide |
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| Name: | biotinylated SRC-1 peptide |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 3157.52 |
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| Organism: | n/a |
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| Description: | A biotinylated peptide comprises amino acids 675-699 of steroid receptor coactivator 1 (SRC1). |
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| Residue: | 28 |
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| Sequence: | CPSSHSSLTERHKILHRLLQEGSPS-CONH2
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