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Compile Data Set for Download or QSAR

Found 738 hits with Last Name = 'morera' and Initial = 'l'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394369
PNG
(CHEMBL2159781)
Show SMILES O=C(N1CCN(CC1)C(c1ccccc1)c1ccccc1)n1nnc2ccccc12
Show InChI InChI=1S/C24H23N5O/c30-24(29-22-14-8-7-13-21(22)25-26-29)28-17-15-27(16-18-28)23(19-9-3-1-4-10-19)20-11-5-2-6-12-20/h1-14,23H,15-18H2
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 75.7n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Irreversible inhibition of human MAGL using p-nitrophenylpropionate as substrate

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394369
PNG
(CHEMBL2159781)
Show SMILES O=C(N1CCN(CC1)C(c1ccccc1)c1ccccc1)n1nnc2ccccc12
Show InChI InChI=1S/C24H23N5O/c30-24(29-22-14-8-7-13-21(22)25-26-29)28-17-15-27(16-18-28)23(19-9-3-1-4-10-19)20-11-5-2-6-12-20/h1-14,23H,15-18H2
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n/an/a 0.540n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394387
PNG
(CHEMBL2159800)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C19H20N4O/c24-19(23-18-9-5-4-8-17(18)20-21-23)22-12-10-16(11-13-22)14-15-6-2-1-3-7-15/h1-9,16H,10-14H2
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n/an/a 2n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394382
PNG
(CHEMBL2159805)
Show SMILES Clc1cccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)c1
Show InChI InChI=1S/C18H18ClN5O/c19-15-5-3-4-14(12-15)13-22-8-10-23(11-9-22)18(25)24-17-7-2-1-6-16(17)20-21-24/h1-7,12H,8-11,13H2
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n/an/a 2n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432910
PNG
(CHEMBL2376864)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1cccc(O)c1
Show InChI InChI=1S/C17H17N5O2/c1-21(2)17(24)22-16(18-19-20-22)10-12-6-8-13(9-7-12)14-4-3-5-15(23)11-14/h3-9,11,23H,10H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394370
PNG
(CHEMBL2159780)
Show SMILES O=C(N1CCN(Cc2cccc3ccccc23)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C22H21N5O/c28-22(27-21-11-4-3-10-20(21)23-24-27)26-14-12-25(13-15-26)16-18-8-5-7-17-6-1-2-9-19(17)18/h1-11H,12-16H2
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n/an/a 3n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394367
PNG
(CHEMBL2159783)
Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)n1nnc2ccccc12
Show InChI InChI=1S/C18H19N5O/c1-14-6-2-4-8-16(14)21-10-12-22(13-11-21)18(24)23-17-9-5-3-7-15(17)19-20-23/h2-9H,10-13H2,1H3
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n/an/a 3n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394387
PNG
(CHEMBL2159800)
Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C19H20N4O/c24-19(23-18-9-5-4-8-17(18)20-21-23)22-12-10-16(11-13-22)14-15-6-2-1-3-7-15/h1-9,16H,10-14H2
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n/an/a 3n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394394
PNG
(CHEMBL2159776)
Show SMILES O=C(N1CCN(CC1)C(c1ccccc1)c1ccccc1)n1nnc2ncccc12
Show InChI InChI=1S/C23H22N6O/c30-23(29-20-12-7-13-24-22(20)25-26-29)28-16-14-27(15-17-28)21(18-8-3-1-4-9-18)19-10-5-2-6-11-19/h1-13,21H,14-17H2
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n/an/a 4n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of MAGL

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432901
PNG
(CHEMBL2376851)
Show SMILES CN(C)C(=O)n1nnc(Cc2ccc(cc2)-c2ccc(O)cc2)n1
Show InChI InChI=1S/C17H17N5O2/c1-21(2)17(24)22-19-16(18-20-22)11-12-3-5-13(6-4-12)14-7-9-15(23)10-8-14/h3-10,23H,11H2,1-2H3
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n/an/a 5.40n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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n/an/a 6.70n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as decrease in intracellular calcium level

Bioorg Med Chem Lett 19: 6806-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.033
BindingDB Entry DOI: 10.7270/Q2P55NNT
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394375
PNG
(CHEMBL2159812)
Show SMILES O=C(Nc1ccccc1)c1cccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)c1
Show InChI InChI=1S/C25H24N6O2/c32-24(26-21-9-2-1-3-10-21)20-8-6-7-19(17-20)18-29-13-15-30(16-14-29)25(33)31-23-12-5-4-11-22(23)27-28-31/h1-12,17H,13-16,18H2,(H,26,32)
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n/an/a 7n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432900
PNG
(CHEMBL2376852)
Show SMILES CN(C)C(=O)n1nnc(Cc2ccc(cc2)-c2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H18N6O2/c1-23(2)18(26)24-21-16(20-22-24)10-12-6-8-13(9-7-12)14-4-3-5-15(11-14)17(19)25/h3-9,11H,10H2,1-2H3,(H2,19,25)
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n/an/a 7.10n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432923
PNG
(CHEMBL2376869)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C18H19N5O/c1-13-4-8-15(9-5-13)16-10-6-14(7-11-16)12-17-19-20-21-23(17)18(24)22(2)3/h4-11H,12H2,1-3H3
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n/an/a 7.10n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432904
PNG
(CHEMBL2376848)
Show SMILES CN(C)C(=O)n1nnc(Cc2ccc(cc2)-c2ccc(CO)cc2)n1
Show InChI InChI=1S/C18H19N5O2/c1-22(2)18(25)23-20-17(19-21-23)11-13-3-7-15(8-4-13)16-9-5-14(12-24)6-10-16/h3-10,24H,11-12H2,1-2H3
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n/an/a 7.5n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394389
PNG
(CHEMBL2159798)
Show SMILES O=C(N1CCN(Cc2ccccc2)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C18H19N5O/c24-18(23-17-9-5-4-8-16(17)19-20-23)22-12-10-21(11-13-22)14-15-6-2-1-3-7-15/h1-9H,10-14H2
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n/an/a 8n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394381
PNG
(CHEMBL2159806)
Show SMILES [O-][N+](=O)c1cccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)c1
Show InChI InChI=1S/C18H18N6O3/c25-18(23-17-7-2-1-6-16(17)19-20-23)22-10-8-21(9-11-22)13-14-4-3-5-15(12-14)24(26)27/h1-7,12H,8-11,13H2
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n/an/a 8n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394373
PNG
(CHEMBL2159777)
Show SMILES O=C(N1CCN(Cc2cccc(c2)-c2ccccc2)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C24H23N5O/c30-24(29-23-12-5-4-11-22(23)25-26-29)28-15-13-27(14-16-28)18-19-7-6-10-21(17-19)20-8-2-1-3-9-20/h1-12,17H,13-16,18H2
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n/an/a 9n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394382
PNG
(CHEMBL2159805)
Show SMILES Clc1cccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)c1
Show InChI InChI=1S/C18H18ClN5O/c19-15-5-3-4-14(12-15)13-22-8-10-23(11-9-22)18(25)24-17-7-2-1-6-16(17)20-21-24/h1-7,12H,8-11,13H2
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n/an/a 9n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394371
PNG
(CHEMBL2159779)
Show SMILES O=C(N1CCN(Cc2ccc3ccccc3c2)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C22H21N5O/c28-22(27-21-8-4-3-7-20(21)23-24-27)26-13-11-25(12-14-26)16-17-9-10-18-5-1-2-6-19(18)15-17/h1-10,15H,11-14,16H2
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n/an/a 9n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394384
PNG
(CHEMBL2159803)
Show SMILES Brc1ccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)cc1
Show InChI InChI=1S/C18H18BrN5O/c19-15-7-5-14(6-8-15)13-22-9-11-23(12-10-22)18(25)24-17-4-2-1-3-16(17)20-21-24/h1-8H,9-13H2
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n/an/a 9n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432924
PNG
(CHEMBL2376868)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1cccc(C)c1
Show InChI InChI=1S/C18H19N5O/c1-13-5-4-6-16(11-13)15-9-7-14(8-10-15)12-17-19-20-21-23(17)18(24)22(2)3/h4-11H,12H2,1-3H3
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n/an/a 9.70n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50432902
PNG
(CHEMBL2376850)
Show SMILES CN(C)C(=O)n1nnc(Cc2ccc(cc2)-c2cccc(O)c2)n1
Show InChI InChI=1S/C17H17N5O2/c1-21(2)17(24)22-19-16(18-20-22)10-12-6-8-13(9-7-12)14-4-3-5-15(23)11-14/h3-9,11,23H,10H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of MAGL (unknown origin) expressed in African green monkey COS7 cell cytosolic fraction assessed as [3H]2-AG hydrolysis to [3H]arachidonic...

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM60622
PNG
(BDBM50300355 | US11753371, Compound JZL-184 | US91...)
Show SMILES OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+]([O-])=O)(c1ccc2OCOc2c1)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H24N2O9/c30-26(38-21-5-3-20(4-6-21)29(32)33)28-11-9-17(10-12-28)27(31,18-1-7-22-24(13-18)36-15-34-22)19-2-8-23-25(14-19)37-16-35-23/h1-8,13-14,17,31H,9-12,15-16H2
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n/an/a 10n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of MAGL

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394386
PNG
(CHEMBL2159801)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)cc1
Show InChI InChI=1S/C18H18FN5O/c19-15-7-5-14(6-8-15)13-22-9-11-23(12-10-22)18(25)24-17-4-2-1-3-16(17)20-21-24/h1-8H,9-13H2
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n/an/a 10n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432913
PNG
(CHEMBL2376861)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1cccc(CO)c1
Show InChI InChI=1S/C18H19N5O2/c1-22(2)18(25)23-17(19-20-21-23)11-13-6-8-15(9-7-13)16-5-3-4-14(10-16)12-24/h3-10,24H,11-12H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394390
PNG
(CHEMBL2159797)
Show SMILES O=C(N1CCN(CC1)c1ccccc1)n1nnc2ccccc12
Show InChI InChI=1S/C17H17N5O/c23-17(22-16-9-5-4-8-15(16)18-19-22)21-12-10-20(11-13-21)14-6-2-1-3-7-14/h1-9H,10-13H2
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n/an/a 11n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394385
PNG
(CHEMBL2159802)
Show SMILES Clc1ccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)cc1
Show InChI InChI=1S/C18H18ClN5O/c19-15-7-5-14(6-8-15)13-22-9-11-23(12-10-22)18(25)24-17-4-2-1-3-16(17)20-21-24/h1-8H,9-13H2
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n/an/a 11n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432905
PNG
(CHEMBL2376847)
Show SMILES CN(C)C(=O)n1nnc(Cc2ccc(cc2)-c2cccc(CO)c2)n1
Show InChI InChI=1S/C18H19N5O2/c1-22(2)18(25)23-20-17(19-21-23)11-13-6-8-15(9-7-13)16-5-3-4-14(10-16)12-24/h3-10,24H,11-12H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432908
PNG
(CHEMBL2376866)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C18H18N6O2/c1-23(2)18(26)24-16(20-21-22-24)10-12-6-8-13(9-7-12)14-4-3-5-15(11-14)17(19)25/h3-9,11H,10H2,1-2H3,(H2,19,25)
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n/an/a 11n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432902
PNG
(CHEMBL2376850)
Show SMILES CN(C)C(=O)n1nnc(Cc2ccc(cc2)-c2cccc(O)c2)n1
Show InChI InChI=1S/C17H17N5O2/c1-21(2)17(24)22-19-16(18-20-22)10-12-6-8-13(9-7-12)14-4-3-5-15(23)11-14/h3-9,11,23H,10H2,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432914
PNG
(CHEMBL2376860)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(Cc2nnnn2C(=O)N(C)C)cc1
Show InChI InChI=1S/C19H19N5O3/c1-23(2)19(26)24-17(20-21-22-24)11-13-7-9-14(10-8-13)15-5-4-6-16(12-15)18(25)27-3/h4-10,12H,11H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432906
PNG
(CHEMBL2376846)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(Cc2nnn(n2)C(=O)N(C)C)cc1
Show InChI InChI=1S/C19H19N5O3/c1-23(2)19(26)24-21-17(20-22-24)11-13-7-9-14(10-8-13)15-5-4-6-16(12-15)18(25)27-3/h4-10,12H,11H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394383
PNG
(CHEMBL2159804)
Show SMILES [O-][N+](=O)c1ccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)cc1
Show InChI InChI=1S/C18H18N6O3/c25-18(23-17-4-2-1-3-16(17)19-20-23)22-11-9-21(10-12-22)13-14-5-7-15(8-6-14)24(26)27/h1-8H,9-13H2
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n/an/a 12n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432921
PNG
(CHEMBL2376843)
Show SMILES CN(CCCCc1ccccc1)C(=O)n1nnc(Cc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C26H27N5O/c1-30(19-9-8-12-21-10-4-2-5-11-21)26(32)31-28-25(27-29-31)20-22-15-17-24(18-16-22)23-13-6-3-7-14-23/h2-7,10-11,13-18H,8-9,12,19-20H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394371
PNG
(CHEMBL2159779)
Show SMILES O=C(N1CCN(Cc2ccc3ccccc3c2)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C22H21N5O/c28-22(27-21-8-4-3-7-20(21)23-24-27)26-13-11-25(12-14-26)16-17-9-10-18-5-1-2-6-19(18)15-17/h1-10,15H,11-14,16H2
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n/an/a 12n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394370
PNG
(CHEMBL2159780)
Show SMILES O=C(N1CCN(Cc2cccc3ccccc23)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C22H21N5O/c28-22(27-21-11-4-3-10-20(21)23-24-27)26-14-12-25(13-15-26)16-18-8-5-7-17-6-1-2-9-19(17)18/h1-11H,12-16H2
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n/an/a 13n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394376
PNG
(CHEMBL2159811)
Show SMILES O=C(NC1CCCCC1)c1cccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)c1
Show InChI InChI=1S/C25H30N6O2/c32-24(26-21-9-2-1-3-10-21)20-8-6-7-19(17-20)18-29-13-15-30(16-14-29)25(33)31-23-12-5-4-11-22(23)27-28-31/h4-8,11-12,17,21H,1-3,9-10,13-16,18H2,(H,26,32)
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n/an/a 13n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394368
PNG
(CHEMBL2159782)
Show SMILES Fc1ccccc1N1CCN(CC1)C(=O)n1nnc2ccccc12
Show InChI InChI=1S/C17H16FN5O/c18-13-5-1-3-7-15(13)21-9-11-22(12-10-21)17(24)23-16-8-4-2-6-14(16)19-20-23/h1-8H,9-12H2
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n/an/a 13n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394363
PNG
(CHEMBL2159787)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(=O)n1nnc2ccccc12
Show InChI InChI=1S/C18H19N5O2/c1-25-15-8-6-14(7-9-15)21-10-12-22(13-11-21)18(24)23-17-5-3-2-4-16(17)19-20-23/h2-9H,10-13H2,1H3
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n/an/a 15n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432915
PNG
(CHEMBL2376859)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1cccc(c1)C(C)=O
Show InChI InChI=1S/C19H19N5O2/c1-13(25)16-5-4-6-17(12-16)15-9-7-14(8-10-15)11-18-20-21-22-24(18)19(26)23(2)3/h4-10,12H,11H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394386
PNG
(CHEMBL2159801)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)cc1
Show InChI InChI=1S/C18H18FN5O/c19-15-7-5-14(6-8-15)13-22-9-11-23(12-10-22)18(25)24-17-4-2-1-3-16(17)20-21-24/h1-8H,9-13H2
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n/an/a 15n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432911
PNG
(CHEMBL2376863)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccccc1O
Show InChI InChI=1S/C17H17N5O2/c1-21(2)17(24)22-16(18-19-20-22)11-12-7-9-13(10-8-12)14-5-3-4-6-15(14)23/h3-10,23H,11H2,1-2H3
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n/an/a 16n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432909
PNG
(CHEMBL2376865)
Show SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccc(O)cc1
Show InChI InChI=1S/C17H17N5O2/c1-21(2)17(24)22-16(18-19-20-22)11-12-3-5-13(6-4-12)14-7-9-15(23)10-8-14/h3-10,23H,11H2,1-2H3
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n/an/a 17n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50432920
PNG
(CHEMBL2376844)
Show SMILES CN(Cc1ccc2ccccc2c1)C(=O)n1nnc(Cc2ccc(cc2)-c2ccccc2)n1
Show InChI InChI=1S/C27H23N5O/c1-31(19-21-13-16-23-9-5-6-10-25(23)17-21)27(33)32-29-26(28-30-32)18-20-11-14-24(15-12-20)22-7-3-2-4-8-22/h2-17H,18-19H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysis

Eur J Med Chem 63: 118-32 (2013)


Article DOI: 10.1016/j.ejmech.2013.02.005
BindingDB Entry DOI: 10.7270/Q2K64KFB
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394385
PNG
(CHEMBL2159802)
Show SMILES Clc1ccc(CN2CCN(CC2)C(=O)n2nnc3ccccc23)cc1
Show InChI InChI=1S/C18H18ClN5O/c19-15-7-5-14(6-8-15)13-22-9-11-23(12-10-22)18(25)24-17-4-2-1-3-16(17)20-21-24/h1-8H,9-13H2
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n/an/a 17n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394374
PNG
(CHEMBL2159813)
Show SMILES O=C(N1CCN(Cc2ccc(cc2)-c2ccccc2)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C24H23N5O/c30-24(29-23-9-5-4-8-22(23)25-26-29)28-16-14-27(15-17-28)18-19-10-12-21(13-11-19)20-6-2-1-3-7-20/h1-13H,14-18H2
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n/an/a 18n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394366
PNG
(CHEMBL2159784)
Show SMILES [O-][N+](=O)c1ccccc1N1CCN(CC1)C(=O)n1nnc2ccccc12
Show InChI InChI=1S/C17H16N6O3/c24-17(22-14-6-2-1-5-13(14)18-19-22)21-11-9-20(10-12-21)15-7-3-4-8-16(15)23(25)26/h1-8H,9-12H2
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n/an/a 19n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50394389
PNG
(CHEMBL2159798)
Show SMILES O=C(N1CCN(Cc2ccccc2)CC1)n1nnc2ccccc12
Show InChI InChI=1S/C18H19N5O/c24-18(23-17-9-5-4-8-16(17)19-20-23)22-12-10-21(11-13-22)14-15-6-2-1-3-7-15/h1-9H,10-14H2
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n/an/a 19n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH assessed as [3H]-AEA hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liq...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50394357
PNG
(CHEMBL2159795)
Show SMILES [O-][N+](=O)c1ccc(cc1C(=O)Nc1ccccc1)N1CCN(CC1)C(=O)n1nnc2ccccc12
Show InChI InChI=1S/C24H21N7O4/c32-23(25-17-6-2-1-3-7-17)19-16-18(10-11-21(19)31(34)35)28-12-14-29(15-13-28)24(33)30-22-9-5-4-8-20(22)26-27-30/h1-11,16H,12-15H2,(H,25,32)
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n/an/a 19n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human MAGL assessed as [3H]-2-OG hydrolysis preincubated for 30 mins before [3H]-2-OG addition measured after 10 mins by liquid scintil...

Bioorg Med Chem 20: 6260-75 (2012)


Article DOI: 10.1016/j.bmc.2012.09.011
BindingDB Entry DOI: 10.7270/Q2W37XDX
More data for this
Ligand-Target Pair
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