| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50432902 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_956682 (CHEMBL2379079) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Ortar, G; Morera, E; De Petrocellis, L; Ligresti, A; Schiano Moriello, A; Morera, L; Nalli, M; Ragno, R; Pirolli, A; Di Marzo, V Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring. Eur J Med Chem63:118-32 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50432902 |
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| n/a |
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| Name | BDBM50432902 |
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| Synonyms: | CHEMBL2376850 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N5O2 |
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| Mol. Mass. | 323.3492 |
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| SMILES | CN(C)C(=O)n1nnc(Cc2ccc(cc2)-c2cccc(O)c2)n1 |
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| Structure | 
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