Reaction Details |
| Report a problem with these data |
Target | Coagulation factor XI |
---|
Ligand | BDBM241535 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibition Assay |
---|
Ki | 0.810±n/a nM |
---|
Citation | Yang, W; Corte, JR; Gilligan, PJ; Pinto, DJ; Ewing, WR; Dilger, AK; Wang, Y; Fang, T; Pabbisetty, KB; Smith, II, LM Dihydropyridone P1 as factor XIa inhibitors US Patent US9951071 Publication Date 4/24/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Coagulation factor XI |
---|
Name: | Coagulation factor XI |
Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
Type: | Enzyme |
Mol. Mass.: | 70130.58 |
Organism: | Homo sapiens (Human) |
Description: | P03951 |
Residue: | 625 |
Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
|
|
|
BDBM241535 |
---|
n/a |
---|
Name | BDBM241535 |
Synonyms: | US9409908, 167 | US9951071, Example 167 |
Type | Small organic molecule |
Emp. Form. | C31H27BrClFN2O4 |
Mol. Mass. | 625.912 |
SMILES | C[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)c(Cl)ccc2Br)c2cccc(c2)-c2cc(ccc2NC1=O)C(O)=O |r,c:9| |
Structure |
|