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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Calcium-dependent protein kinase 1 | ||
| Ligand | BDBM286300 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 13.0±n/a nM | ||
| Citation |  Fan, E; Van Voorhis, WC; Zhang, Z; Huang, W; Ojo, KK 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum US Patent US9956214 Publication Date 5/1/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Calcium-dependent protein kinase 1 | |||
| Name: | Calcium-dependent protein kinase 1 | ||
| Synonyms: | Calcium-dependent protein kinase 1 (CDPK1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 76617.33 | ||
| Organism: | Cryptosporidium parvum | ||
| Description: | Q6S4W0 | ||
| Residue: | 677 | ||
| Sequence: |
| ||
| BDBM286300 | |||
| n/a | |||
| Name | BDBM286300 | ||
| Synonyms: | 5-amino-3-(7-ethoxyquinolin-3- yl)-1-(3-hydroxy-3-methylbutan- 2-yl)-1H-pyrazole-4-carboxamide 1H NMR (500 MHz, MeOD) $#948; 9.31 (s, 1H), 9.26 (s, 1H), 8.30 (d, J = 9.2 Hz, 1H), 7.62 (d, J = 9.2 Hz, 1H), 7.54 (s, 1H), 4.38 (q, J = 7.0 Hz, 2H), 4.36-4.29 (m, 1H), 1.59-1.53 (m, 6H), 1.30 (s, 3H), 1.26 (s, 3H), MS (ESI) (M + H)+ = 384.6 | US9518026, Example 93 | US9956214, Compound 1626 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H25N5O3 | ||
| Mol. Mass. | 383.4442 | ||
| SMILES | CCOc1ccc2cc(cnc2c1)-c1nn(C(C)C(C)(C)O)c(N)c1C(N)=O | ||
| Structure | 
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