Reaction Details |
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Target | Poly [ADP-ribose] polymerase 2 |
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Ligand | BDBM27716 |
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Substrate/Competitor | BDBM27683 |
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Meas. Tech. | PARP Enzyme Inhibition Assay |
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Temperature | 298.15±n/a K |
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IC50 | 90±n/a nM |
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Comments | extracted |
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Citation | Ishida, J; Yamamoto, H; Kido, Y; Kamijo, K; Murano, K; Miyake, H; Ohkubo, M; Kinoshita, T; Warizaya, M; Iwashita, A; Mihara, K; Matsuoka, N; Hattori, K Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling. Bioorg Med Chem14:1378-90 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Poly [ADP-ribose] polymerase 2 |
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Name: | Poly [ADP-ribose] polymerase 2 |
Synonyms: | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2) |
Type: | n/a |
Mol. Mass.: | 63409.97 |
Organism: | Mus musculus (Mouse) |
Description: | Alexis Biochemicals, Cat. no. ALX-201-064-C020 |
Residue: | 559 |
Sequence: | MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNR
DSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDD
AQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGK
YDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKR
APLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTE
KELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQ
YLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLR
VAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPK
AQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSP
NQVRMRYLLKIQFNFLQLW
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BDBM27716 |
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BDBM27683 |
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Name | BDBM27716 |
Synonyms: | 4-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)phthalazin-1(2H)-one | 4-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-2H-phthalazin-1-one | 4-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-1,2-dihydrophthalazin-1-one | CHEMBL425201 | phthalazinone analogue, 9a |
Type | Small organic molecule |
Emp. Form. | C23H25N3O |
Mol. Mass. | 359.4641 |
SMILES | O=c1[nH]nc(CCCCN2CCC(=CC2)c2ccccc2)c2ccccc12 |c:12| |
Structure |
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