| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
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| Ligand | BDBM27718 |
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| Substrate/Competitor | BDBM27683 |
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| Meas. Tech. | PARP Enzyme Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 84±n/a nM |
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| Comments | extracted |
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| Citation |  Ishida, J; Yamamoto, H; Kido, Y; Kamijo, K; Murano, K; Miyake, H; Ohkubo, M; Kinoshita, T; Warizaya, M; Iwashita, A; Mihara, K; Matsuoka, N; Hattori, K Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling. Bioorg Med Chem14:1378-90 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Poly [ADP-ribose] polymerase 2 |
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| Name: | Poly [ADP-ribose] polymerase 2 |
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| Synonyms: | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2) |
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| Type: | n/a |
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| Mol. Mass.: | 63409.97 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Alexis Biochemicals, Cat. no. ALX-201-064-C020 |
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| Residue: | 559 |
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| Sequence: | MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNR
DSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDD
AQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGK
YDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKR
APLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTE
KELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQ
YLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLR
VAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPK
AQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSP
NQVRMRYLLKIQFNFLQLW
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| BDBM27718 |
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| BDBM27683 |
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| Name | BDBM27718 |
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| Synonyms: | 2-(3-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)propyl)phenanthridin-6(5H)-one | 2-[3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-propyl]-5H-phenanthridin-6-one | 2-[3-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)propyl]-5,6-dihydrophenanthridin-6-one | CHEMBL194482 | phenanthridinone analogue, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26N2O |
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| Mol. Mass. | 394.5081 |
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| SMILES | O=c1[nH]c2ccc(CCCN3CCC(=CC3)c3ccccc3)cc2c2ccccc12 |c:13| |
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| Structure | 
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