Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM27774 |
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Substrate/Competitor | BDBM25143 |
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Meas. Tech. | HDAC Activity Assay |
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pH | 8±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 4±n/a nM |
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Citation | Kattar, SD; Surdi, LM; Zabierek, A; Methot, JL; Middleton, RE; Hughes, B; Szewczak, AA; Dahlberg, WK; Kral, AM; Ozerova, N; Fleming, JC; Wang, H; Secrist, P; Harsch, A; Hamill, JE; Cruz, JC; Kenific, CM; Chenard, M; Miller, TA; Berk, SC; Tempest, P Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization. Bioorg Med Chem Lett19:1168-72 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM27774 |
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BDBM25143 |
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Name | BDBM27774 |
Synonyms: | N-[2-amino-5-(thiophen-2-yl)phenyl]-4-{1,8-diazaspiro[4.5]decan-8-ylmethyl}benzamide | biphenyl diamine analogue, 22 |
Type | Small organic molecule |
Emp. Form. | C26H30N4OS |
Mol. Mass. | 446.608 |
SMILES | Nc1ccc(cc1NC(=O)c1ccc(CN2CCC3(CCCN3)CC2)cc1)-c1cccs1 |
Structure |
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