Ki Summary

Reaction Details

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Target

Bromodomain-containing protein 4

Ligand

BDBM50260084

Substrate/Competitor

n/a

Meas. Tech.

TR-FRET Assay (BD1: amino acids K57-E168)

1.10±n/a nM

Citation

Dai, Y; Fidanze, SD; Hasvold, L; Holms, J; Liu, D; McClellan, W; McDaniel, K; Marjanovic, J; Sheppard, G; Wang, L Bromodomain inhibitors US Patent US9957263 Publication Date 5/1/2018

More Info.:

Get all data from this article, Assay Method

Bromodomain-containing protein 4

Name:

Bromodomain-containing protein 4

Synonyms:

BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 | Protein HUNK1

Type:

Protein

Mol. Mass.:

152264.84

Organism:

Homo sapiens (Human)

Description:

O60885

Residue:

1362

Sequence:

MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF

BDBM50260084

n/a

Name

BDBM50260084

Synonyms:

CHEMBL4096313 | US9957263, Example 110

Type

Small organic molecule

Emp. Form.

C32H34N4O3S

Mol. Mass.

554.702

SMILES

Cn1cc(-c2cc(ccc2N[C@H]2CC[C@@H](CC2)NCc2ccc3ccccc3c2)S(C)(=O)=O)c2cc[nH]c2c1=O |r,wU:11.11,wD:14.18,(58.54,-.63,;59.88,-1.39,;59.89,-2.94,;61.23,-3.69,;61.24,-5.24,;62.58,-5.99,;62.59,-7.54,;61.25,-8.32,;59.92,-7.55,;59.92,-6.02,;58.58,-5.25,;57.25,-6.03,;57.26,-7.56,;55.92,-8.34,;54.58,-7.57,;54.58,-6.03,;55.91,-5.26,;53.25,-8.34,;51.91,-7.57,;50.58,-8.34,;50.58,-9.87,;49.25,-10.64,;47.91,-9.87,;46.58,-10.64,;45.25,-9.88,;45.25,-8.33,;46.58,-7.56,;47.91,-8.33,;49.24,-7.56,;63.93,-8.31,;63.93,-9.85,;64.69,-6.97,;65.47,-8.3,;62.55,-2.91,;64.01,-3.38,;64.9,-2.14,;64,-.9,;62.55,-1.38,;61.21,-.61,;61.2,.94,)|

Structure