Reaction Details | |||
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Target | Bromodomain-containing protein 4 | ||
Ligand | BDBM390847 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TR-FRET Assay (BD1: amino acids K57-E168) | ||
Ki | 4.60±n/a nM | ||
Citation | Dai, Y; Fidanze, SD; Hasvold, L; Holms, J; Liu, D; McClellan, W; McDaniel, K; Marjanovic, J; Sheppard, G; Wang, L Bromodomain inhibitors US Patent US9957263 Publication Date 5/1/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 4 | |||
Name: | Bromodomain-containing protein 4 | ||
Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 | Protein HUNK1 | ||
Type: | Protein | ||
Mol. Mass.: | 152264.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60885 | ||
Residue: | 1362 | ||
Sequence: |
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BDBM390847 | |||
n/a | |||
Name | BDBM390847 | ||
Synonyms: | US9957263, Example 111 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H32N4O4S | ||
Mol. Mass. | 472.6 | ||
SMILES | COCCN[C@H]1CC[C@@H](CC1)Nc1ccc(cc1-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O |r,wU:8.11,wD:5.4,(-9.34,-10.01,;-8,-9.24,;-8,-7.7,;-6.67,-6.93,;-6.67,-5.39,;-5.33,-4.62,;-4,-5.39,;-2.67,-4.62,;-2.67,-3.08,;-4,-2.31,;-5.33,-3.08,;-1.33,-2.31,;,-3.08,;,-4.62,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;4,2.31,;1.33,2.31,;1.33,3.85,;,1.54,;-1.46,2.02,;-2.37,.77,;-1.46,-.48,;;4,-5.39,;4.77,-4.06,;5.33,-6.16,;3.23,-6.72,)| | ||
Structure |