Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP [241-356] |
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Ligand | BDBM27942 |
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Substrate/Competitor | BDBM17342 |
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Meas. Tech. | Fluorescence Polarization Affinity Measurements |
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Ki | 345±n/a nM |
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Citation | Cohen, F; Alicke, B; Elliott, LO; Flygare, JA; Goncharov, T; Keteltas, SF; Franklin, MC; Frankovitz, S; Stephan, JP; Tsui, V; Vucic, D; Wong, H; Fairbrother, WJ Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem52:1723-30 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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E3 ubiquitin-protein ligase XIAP [241-356] |
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Name: | E3 ubiquitin-protein ligase XIAP [241-356] |
Synonyms: | API3 | BIR3 domain of X-linked inhibitor of apoptosis protein | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR3) | E3 ubiquitin-protein ligase XIAP BIR-3 | E3 ubiquitin-protein ligase XIAP BIR3 | IAP3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP | XIAP-BIR3 | XIAP_HUMAN | baculovirus IAP repeat 3 (BIR3) domain of XIAP |
Type: | Protein Binding Domain |
Mol. Mass.: | 13276.62 |
Organism: | Homo sapiens (Human) |
Description: | BIR3 of XIAP: RESIDUES 241-356. |
Residue: | 116 |
Sequence: | SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
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BDBM27942 |
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BDBM17342 |
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Name | BDBM27942 |
Synonyms: | (2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]-N-(2,2-diphenylethyl)pyrrolidine-2-carboxamide | Ala-Val-Pro-2,2-diphenethylamine, 1 |
Type | n/a |
Emp. Form. | C27H36N4O3 |
Mol. Mass. | 464.5997 |
SMILES | CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)NCC(c1ccccc1)c1ccccc1 |r| |
Structure |
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