Reaction Details |
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Target | Steroidogenic factor 1 |
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Ligand | BDBM28647 |
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Substrate/Competitor | BDBM10852 |
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Meas. Tech. | Transactivation Cell-Based Assay |
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EC50 | 200±40 nM |
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Citation | Roth, J; Madoux, F; Hodder, P; Roush, WR Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg Med Chem Lett18:2628-32 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Steroidogenic factor 1 |
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Name: | Steroidogenic factor 1 |
Synonyms: | AD4BP | Adrenal 4-binding protein | FTZF1 | Fushi tarazu factor homolog 1 | NR5A1 | Nuclear receptor subfamily 5 group A member 1 | SF-1 | SF1 | STF-1 | STF1_HUMAN | Steroid hormone receptor Ad4BP |
Type: | Nuclear Hormone Receptor |
Mol. Mass.: | 51643.43 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 461 |
Sequence: | MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKT
QRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKL
ETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPL
AGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQV
RARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQN
CWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLA
LQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLL
LCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
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BDBM28647 |
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BDBM10852 |
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Name | BDBM28647 |
Synonyms: | ethyl 2-[(2-{[(4-methoxyphenyl)carbamoyl]methyl}-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate | isoquinolinone scaffold, 31 |
Type | Small organic molecule |
Emp. Form. | C23H24N2O6 |
Mol. Mass. | 424.4465 |
SMILES | CCOC(=O)C(C)Oc1cccc2c1ccn(CC(=O)Nc1ccc(OC)cc1)c2=O |
Structure |
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