| Reaction Details |
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 | Report a problem with these data |
| Target | Steroidogenic factor 1 |
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| Ligand | BDBM28648 |
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| Substrate/Competitor | BDBM10852 |
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| Meas. Tech. | Transactivation Cell-Based Assay |
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| EC50 | 200±110 nM |
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| Citation |  Roth, J; Madoux, F; Hodder, P; Roush, WR Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg Med Chem Lett18:2628-32 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Steroidogenic factor 1 |
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| Name: | Steroidogenic factor 1 |
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| Synonyms: | AD4BP | Adrenal 4-binding protein | FTZF1 | Fushi tarazu factor homolog 1 | NR5A1 | Nuclear receptor subfamily 5 group A member 1 | SF-1 | SF1 | STF-1 | STF1_HUMAN | Steroid hormone receptor Ad4BP |
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| Type: | Nuclear Hormone Receptor |
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| Mol. Mass.: | 51643.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 461 |
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| Sequence: | MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKT
QRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKL
ETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPL
AGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQV
RARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQN
CWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLA
LQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLL
LCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
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| BDBM28648 |
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| BDBM10852 |
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| Name | BDBM28648 |
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| Synonyms: | ethyl 2-{[1-oxo-2-({[4-(trifluoromethoxy)phenyl]carbamoyl}methyl)-1,2-dihydroisoquinolin-5-yl]oxy}propanoate | isoquinolinone scaffold, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21F3N2O6 |
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| Mol. Mass. | 478.4178 |
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| SMILES | CCOC(=O)C(C)Oc1cccc2c1ccn(CC(=O)Nc1ccc(OC(F)(F)F)cc1)c2=O |
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| Structure | 
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