| Reaction Details |
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 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Ligand | BDBM347376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | in vitro assay |
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| IC50 | 18.0±n/a nM |
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| Citation |  Markowitz, S; Willson, JK; Posner, B; Ready, J; Zhang, Y; Tai, H; Antczak, M; Gerson, S; Bae, K; Yang, SY; Desai, A Compositions and methods of modulating 15-PGDH activity US Patent US10301320 Publication Date 5/28/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28974.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15428 |
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| Residue: | 266 |
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| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
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| BDBM347376 |
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| n/a |
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| Name | BDBM347376 |
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| Synonyms: | US10301320, ID SW208081 | US10869871, ID # SW208081 | US20230285402, ID # SW208081 | US9789116, SW208081 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N2OS3 |
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| Mol. Mass. | 440.644 |
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| SMILES | CCCCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1 |
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| Structure | 
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