Reaction Details |
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Target | Dimer of Gag-Pol polyprotein [489-587] |
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Ligand | BDBM535 |
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Substrate/Competitor | HIV-1 Peptide Substrate |
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Meas. Tech. | Protease Inhibition Assay |
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pH | 5.5±n/a |
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Temperature | 303.15±n/a K |
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IC50 | 82±n/a nM |
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Citation | Ghosh, AK; Lee, HY; Thompson, WJ; Culberson, C; Holloway, MK; McKee, SP; Munson, PM; Duong, TT; Smith, AM; Darke, PL The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors. J Med Chem37:1177-88 (1994) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Dimer of Gag-Pol polyprotein [489-587] |
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Name: | Dimer of Gag-Pol polyprotein [489-587] |
Synonyms: | HIV-1 Protease |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10822.21 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P12497[489-587] |
Residue: | 99 |
Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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Component 2 |
Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10822.21 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P12497[489-587] |
Residue: | 99 |
Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM535 |
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HIV-1 Peptide Substrate |
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Name: | HIV-1 Peptide Substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 4333.31 |
Organism: | n/a |
Description: | n/a |
Residue: | 40 |
Sequence: | H-Val-Ser-Gln-Asn-(L-beta-napthylalanine)-Pro-Ile-Val-OH
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