Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 |
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Ligand | BDBM31283 |
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Substrate/Competitor | BDBM10852 |
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Meas. Tech. | NMR Titration Experiment |
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pH | 7.4±n/a |
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Temperature | 296.15±n/a K |
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Kd | 270000±n/a nM |
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Citation | Stoll, R; Renner, C; Hansen, S; Palme, S; Klein, C; Belling, A; Zeslawski, W; Kamionka, M; Rehm, T; Mühlhahn, P; Schumacher, R; Hesse, F; Kaluza, B; Voelter, W; Engh, RA; Holak, TA Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. Biochemistry40:336-44 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 |
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Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM31283 |
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BDBM10852 |
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Name | BDBM31283 |
Synonyms: | Chalcone derivative, N |
Type | Small organic molecule |
Emp. Form. | C21H14Br2O4 |
Mol. Mass. | 490.141 |
SMILES | OC(=O)COc1c(Br)cc(\C=C\C(=O)c2ccc3ccccc3c2)cc1Br |
Structure |
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