Ki Summary

Reaction Details

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Target

Neuronal acetylcholine receptor subunit alpha-7

Ligand

BDBM397138

Substrate/Competitor

n/a

Meas. Tech.

FlexStation-Ca2+ Influx Assay

EC50

300±n/a nM

Citation

Maeng, CY; Jang, YK; Cha, SB; Shin, HW; Joung, CM; Yi, EJ Pharmaceutical composition comprising pyridone derivatives US Patent US9987259 Publication Date 6/5/2018

More Info.:

Get all data from this article, Assay Method

Neuronal acetylcholine receptor subunit alpha-7

Name:

Neuronal acetylcholine receptor subunit alpha-7

Synonyms:

Type:

n/a

Mol. Mass.:

56448.33

Organism:

Homo sapiens (Human)

Description:

CHRNA7 (NACHRA7)

Residue:

502

Sequence:

MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA

BDBM397138

n/a

Name

BDBM397138

Synonyms:

N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(1,3-benzothiazole-2-yl)-6-oxo-3-pyridinecarboxamide | US10456385, Example 33 | US9987259, Example 33

Type

Small organic molecule

Emp. Form.

C20H20N4O2S

Mol. Mass.

380.463

SMILES

O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nc2ccccc2s1 |(2.37,1.49,;2.37,-.05,;3.71,-.82,;5.04,-.05,;5.04,1.49,;6.37,2.26,;7.71,1.49,;7.71,-.05,;6.37,-.82,;7.14,.51,;5.6,.92,;1.04,-.82,;1.04,-2.36,;-.29,-3.13,;-1.63,-2.36,;-2.96,-3.13,;-1.63,-.82,;-.29,-.05,;-2.96,-.05,;-3.12,1.48,;-4.63,1.8,;-5.4,3.13,;-6.94,3.13,;-7.71,1.8,;-6.94,.47,;-5.4,.47,;-4.37,-.68,)|

Structure