Reaction Details |
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Target | Replicase polyprotein 1ab [1541-1855] |
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Ligand | BDBM31523 |
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Substrate/Competitor | SARS-CoV PLpro Substrate Peptide |
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Meas. Tech. | SARS-CoV PLpro Enzyme Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 296.15±n/a K |
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IC50 | 560±30 nM |
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Citation | Ghosh, AK; Takayama, J; Aubin, Y; Ratia, K; Chaudhuri, R; Baez, Y; Sleeman, K; Coughlin, M; Nichols, DB; Mulhearn, DC; Prabhakar, BS; Baker, SC; Johnson, ME; Mesecar, AD Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease. J Med Chem52:5228-40 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Replicase polyprotein 1ab [1541-1855] |
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Name: | Replicase polyprotein 1ab [1541-1855] |
Synonyms: | R1AB_SARS | SARS Coronavirus Coronavirus Papain-Like Protease | SARS-CoV PLpro | SARS-CoV papain-like protease (SARS-PLpro) | rep |
Type: | Hydrolase |
Mol. Mass.: | 35352.30 |
Organism: | Human SARS coronavirus (SARS-CoV) |
Description: | The SARS-CoV PLpro enzyme (residues 1541 -1855) was expressed and purified from E. coli. |
Residue: | 315 |
Sequence: | EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPS
DDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLAL
QQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLES
AKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESS
FVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPV
TDVFYKETSYTTTIK
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BDBM31523 |
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SARS-CoV PLpro Substrate Peptide |
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Name: | SARS-CoV PLpro Substrate Peptide |
Synonyms: | Arg-Leu-Arg-Gly-Gly-AMC |
Type: | Fluorogenic peptide |
Mol. Mass.: | 865.08 |
Organism: | n/a |
Description: | n/a |
Residue: | 8 |
Sequence: | |