| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2E1 |
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| Ligand | BDBM31656 |
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| Substrate/Competitor | BDBM31678 |
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| Meas. Tech. | Measurement of CYP2E1 Enzymatic Activity |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | >100000±n/a nM |
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| Citation |  Vlahakis, JZ; Hum, M; Rahman, MN; Jia, Z; Nakatsu, K; Szarek, WA Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring. Bioorg Med Chem17:2461-75 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Cytochrome P450 2E1 |
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| Name: | Cytochrome P450 2E1 |
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| Synonyms: | 4-nitrophenol 2-hydroxylase | CP2E1_RAT | CYPIIE1 | Cyp2e | Cyp2e-1 | Cyp2e1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56637.32 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | CYP2E1 prepared from rat liver microsomes was used in enzyme assays. |
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| Residue: | 493 |
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| Sequence: | MAVLGITIALLVWVATLLVISIWKQIYNSWNLPPGPFPLPILGNIFQLDLKDIPKSFTKL
AKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGP
TWKDVRRFSLSILRDWGMGKQGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVI
ADILFNKRFDYNDKKCLRLMSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHRKIMKNVS
EIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQEPMYTMENVSVTLADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRF
INLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGK
FKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGS
IPPQFKLCVIPRS
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| BDBM31656 |
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| BDBM31678 |
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| Name | BDBM31656 |
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| Synonyms: | imidazole-dioxolane, 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22ClN3O2S |
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| Mol. Mass. | 415.936 |
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| SMILES | Clc1ccc(CC[C@@]2(Cn3ccnc3)OC[C@@H](CSc3ccncc3)O2)cc1 |r| |
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| Structure | 
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