| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 3A1 |
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| Ligand | BDBM31682 |
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| Substrate/Competitor | erythromycin |
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| IC50 | 4000±n/a nM |
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| Citation |  Vlahakis, JZ; Hum, M; Rahman, MN; Jia, Z; Nakatsu, K; Szarek, WA Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring. Bioorg Med Chem17:2461-75 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cytochrome P450 3A1 |
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| Name: | Cytochrome P450 3A1 |
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| Synonyms: | CP3A1_RAT | CYPIIIA1 | Cyp3a-1 | Cyp3a1 | P450-PCN1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 57928.74 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | CYP3A1/3A2 prepared from rat liver microsomes was used in enzyme assays. |
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| Residue: | 504 |
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| Sequence: | MDLLSALTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKF
DVECHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAVSV
AKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKPVTMKKVFGAYS
MDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICM
FPKDSIEFFKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQS
IIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMV
LNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERF
SKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSR
QGLLQPTKPIILKVVPRDEIITGS
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| BDBM31682 |
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| erythromycin |
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| Name | BDBM31682 |
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| Synonyms: | imidazole-dioxolane, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18ClFN2O2 |
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| Mol. Mass. | 324.778 |
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| SMILES | FC[C@@H]1CO[C@@](CCc2ccc(Cl)cc2)(Cn2ccnc2)O1 |r| |
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| Structure | 
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