| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM31803 |
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| Substrate/Competitor | FITC-conjugated-Bim BH3 Peptide |
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| Meas. Tech. | Fluorescence Polarization Assay |
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| pH | 7.4±n/a |
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| Temperature | 296.15±n/a K |
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| IC50 | 480±n/a nM |
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| Citation |  Wei, J; Kitada, S; Rega, MF; Stebbins, JL; Zhai, D; Cellitti, J; Yuan, H; Emdadi, A; Dahl, R; Zhang, Z; Yang, L; Reed, JC; Pellecchia, M Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem52:4511-23 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM31803 |
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| FITC-conjugated-Bim BH3 Peptide |
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| Name: | FITC-conjugated-Bim BH3 Peptide |
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| Synonyms: | FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH |
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| Type: | FITC-labeled Peptide |
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| Mol. Mass.: | 3112.46 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 25 |
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| Sequence: | DMRPEIWIAQELRRIGDEFNAYYAR
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