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TargetInduced myeloid leukemia cell differentiation protein Mcl-1
LigandBDBM31803
Substrate/CompetitorFITC-conjugated-Bim BH3 Peptide
Meas. Tech.Fluorescence Polarization Assay
pH7.4±n/a
Temperature296.15±n/a K
IC50 830±n/a nM
Citation Wei, J; Kitada, S; Rega, MF; Stebbins, JL; Zhai, D; Cellitti, J; Yuan, H; Emdadi, A; Dahl, R; Zhang, Z; Yang, L; Reed, JC; Pellecchia, M Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem52:4511-23 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Induced myeloid leukemia cell differentiation protein Mcl-1
Name:Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:Membrane; Single-pass membrane protein
Mol. Mass.:37332.87
Organism:Homo sapiens (Human)
Description:Q07820
Residue:350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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  Blast E-value cutoff:
BDBM31803
FITC-conjugated-Bim BH3 Peptide
Name:FITC-conjugated-Bim BH3 Peptide
Synonyms:FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:FITC-labeled Peptide
Mol. Mass.:3112.46
Organism:n/a
Description:n/a
Residue:25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR