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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Src Mutant (S345C/T338M) | ||
| Ligand | BDBM5446 | ||
| Substrate/Competitor | Tyr 02 Substrate Peptide | ||
| Meas. Tech. | Src IC50 Determination | ||
| pH | 7.5±n/a | ||
| Temperature | 296.15±n/a K | ||
| IC50 | 15000±n/a nM | ||
| Citation |  Michalczyk A; Klüter S; Rode HB; Simard JR; Grütter C; Rabiller M; Rauh D Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg Med Chem 16:3482-8 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Src Mutant (S345C/T338M) | |||
| Name: | Src Mutant (S345C/T338M) | ||
| Synonyms: | Proto-oncogene tyrosine-protein kinase Src | cSRC-DM | ||
| Type: | Tyr protein kinase | ||
| Mol. Mass.: | 32732.47 | ||
| Organism: | Gallus gallus (Chicken) | ||
| Description: | Mutations of T338 to methionine and S345 to cysteine were introduced by site-directed mutagenesis and confirmed by sequence analysis. | ||
| Residue: | 286 | ||
| Sequence: |
| ||
| BDBM5446 | |||
| Tyr 02 Substrate Peptide | |||
| Name: | Tyr 02 Substrate Peptide | ||
| Synonyms: | n/a | ||
| Type: | FRET-peptide substrate | ||
| Mol. Mass.: | 358.43 | ||
| Organism: | n/a | ||
| Description: | n/a | ||
| Residue: | 3 | ||
| Sequence: |
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