| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 [48-359] |
|---|
| Ligand | BDBM32437 |
|---|
| Substrate/Competitor | Serine/threonine-protein kinase Sgk1 |
|---|
| Meas. Tech. | ELISA assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 296.15±n/a K |
|---|
| IC50 | 65±n/a nM |
|---|
| Citation |  Kim, KH; Wissner, A; Floyd, MB; Fraser, HL; Wang, YD; Dushin, RG; Hu, Y; Olland, A; Guo, B; Arndt, K Benzo[c][2,7]naphthyridines as inhibitors of PDK-1. Bioorg Med Chem Lett19:5225-8 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| 3-phosphoinositide-dependent protein kinase 1 [48-359] |
|---|
| Name: | 3-phosphoinositide-dependent protein kinase 1 [48-359] |
|---|
| Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | hPDK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 35527.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15530[48-359] |
|---|
| Residue: | 312 |
|---|
| Sequence: | GPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSRE
YAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGEL
LKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTA
KVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNE
YLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTW
ENLHQQTPPKLT
|
|
|
|---|
| BDBM32437 |
|---|
| Serine/threonine-protein kinase Sgk1 |
|---|
| Name: | Serine/threonine-protein kinase Sgk1 |
|---|
| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 48954.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
|---|
| Residue: | 431 |
|---|
| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
|
|
|
|---|
Search and Browse
