| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] |
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| Ligand | BDBM32459 |
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| Substrate/Competitor | biotinylated-ATF2 |
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| Meas. Tech. | Homogeneous Time-resolved Fluorescence Assay |
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| pH | 7±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 540±n/a nM |
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| Citation |  Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett19:3344-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] |
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| Name: | Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402] |
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| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Alpha-1) [39-402] | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 42009.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53779-2[39-402] |
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| Residue: | 364 |
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| Sequence: | MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK
MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV
MNSE
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| BDBM32459 |
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| biotinylated-ATF2 |
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| Name: | biotinylated-ATF2 |
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| Synonyms: | Activating transcription factor 2 | Cyclic AMP-dependent transcription factor ATF-2 | cAMP response element-binding protein CRE-BP1 |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 13150.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ATF-2 (aa 1-115) was expressed and purified from E. coli. |
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| Residue: | 115 |
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| Sequence: | MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARN
DSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLA
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