| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 |
|---|
| Ligand | BDBM32455 |
|---|
| Substrate/Competitor | biotinylated-ATF2 |
|---|
| Meas. Tech. | Homogeneous Time-resolved Fluorescence Assay |
|---|
| IC50 | 360±n/a nM |
|---|
| Citation |  Shin, Y; Chen, W; Habel, J; Duckett, D; Ling, YY; Koenig, M; He, Y; Vojkovsky, T; LoGrasso, P; Kamenecka, TM Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett19:3344-7 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 8 |
|---|
| Name: | Mitogen-activated protein kinase 8 |
|---|
| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48297.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
|---|
| Residue: | 427 |
|---|
| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
|
|
|
|---|
| BDBM32455 |
|---|
| biotinylated-ATF2 |
|---|
| Name: | biotinylated-ATF2 |
|---|
| Synonyms: | Activating transcription factor 2 | Cyclic AMP-dependent transcription factor ATF-2 | cAMP response element-binding protein CRE-BP1 |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 13150.37 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ATF-2 (aa 1-115) was expressed and purified from E. coli. |
|---|
| Residue: | 115 |
|---|
| Sequence: | MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARN
DSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLA
|
|
|
|---|
Search and Browse
