| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-2C adrenergic receptor |
|---|
| Ligand | BDBM398511 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Antagonism Against Adrenoreceptors |
|---|
| IC50 | 20.0±n/a nM |
|---|
| Citation |  Becker-Pelster, EM; Buchgraber, P; Buchmüller, A; Engel, K; Geiss, V; Göller, A; Himmel, H; Kast, R; Knorr, A; Lang, D; Redlich, G; Schmeck, C; Tinel, H; Wunder, F Substituted piperidinyl tetrahydroquinolines US Patent US10323020 Publication Date 6/18/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-2C adrenergic receptor |
|---|
| Name: | Alpha-2C adrenergic receptor |
|---|
| Synonyms: | ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens] |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49552.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P18825 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
|
|
|
|---|
| BDBM398511 |
|---|
| n/a |
|---|
| Name | BDBM398511 |
|---|
| Synonyms: | (rac)-{2-[(1-Methoxybutan-2-yl)amino]pyrimidin-5-yl}[4-(6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl)piperidin-1-yl]methanone | US10323020, Example 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H35N5O3 |
|---|
| Mol. Mass. | 453.5771 |
|---|
| SMILES | CCC(COC)Nc1ncc(cn1)C(=O)N1CCC(CC1)N1CCc2cc(OC)ccc2C1 |
|---|
| Structure | 
|
|---|
Search and Browse
