| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2C adrenergic receptor |
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| Ligand | BDBM398521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Antagonism Against Adrenoreceptors |
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| IC50 | 68.0±n/a nM |
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| Citation |  Becker-Pelster, EM; Buchgraber, P; Buchmüller, A; Engel, K; Geiss, V; Göller, A; Himmel, H; Kast, R; Knorr, A; Lang, D; Redlich, G; Schmeck, C; Tinel, H; Wunder, F Substituted piperidinyl tetrahydroquinolines US Patent US10323020 Publication Date 6/18/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2C adrenergic receptor |
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| Name: | Alpha-2C adrenergic receptor |
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| Synonyms: | ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens] |
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| Type: | Enzyme |
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| Mol. Mass.: | 49552.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18825 |
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| Residue: | 462 |
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| Sequence: | MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
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| BDBM398521 |
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| n/a |
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| Name | BDBM398521 |
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| Synonyms: | US10323020, Example 15 | [4-(3,4-Dihydroisoquinolin-2(1H)-yl)piperidin-1-yl][2-(2,2-dimethylmorpholin-4-yl)pyrimidin-5-yl]methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C25H33N5O2 |
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| Mol. Mass. | 435.5618 |
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| SMILES | CC1(C)CN(CCO1)c1ncc(cn1)C(=O)N1CCC(CC1)N1CCc2ccccc2C1 |
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| Structure | 
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