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TargetCathepsin S
LigandBDBM33994
Substrate/CompetitorCathepsin S Substrate Peptide
Meas. Tech.Cathepsn S Inhibition Assay
pH5±n/a
Temperature296.15±n/a K
IC50 140±n/a nM
Citation Ameriks, MK; Axe, FU; Bembenek, SD; Edwards, JP; Gu, Y; Karlsson, L; Randal, M; Sun, S; Thurmond, RL; Zhu, J Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements. Bioorg Med Chem Lett19:6131-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM33994
Cathepsin S Substrate Peptide
Name:Cathepsin S Substrate Peptide
Synonyms:n/a
Type:Internally quenched FRET peptide
Mol. Mass.:2951.18
Organism:n/a
Description:n/a
Residue:27
Sequence:
(Aedens)EKARVLAEAA(Dabcyl)K-amide