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Compile Data Set for Download or QSAR

Found 288 hits with Last Name = 'axe' and Initial = 'fu'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127832
PNG
(3-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES Cc1c(cc2ccccn12)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H28N2O/c1-19-23(18-21-8-3-6-16-25(19)21)20-9-11-22(12-10-20)26-17-7-15-24-13-4-2-5-14-24/h3,6,8-12,16,18H,2,4-5,7,13-15,17H2,1H3
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 2n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50120543
PNG
(7-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H27N3O/c1-18-10-14-25-17-21(23-22(25)16-18)19-6-8-20(9-7-19)26-15-5-13-24-11-3-2-4-12-24/h6-10,14,16-17H,2-5,11-13,15H2,1H3
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 2n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127844
PNG
(3-Ethyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-in...)
Show SMILES CCc1c(cc2ccccn12)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C24H30N2O/c1-2-24-23(19-21-9-4-7-17-26(21)24)20-10-12-22(13-11-20)27-18-8-16-25-14-5-3-6-15-25/h4,7,9-13,17,19H,2-3,5-6,8,14-16,18H2,1H3
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 5n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50120542
PNG
(2-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-imidazo[1,...)
Show SMILES C(COc1ccc(cc1)-c1cn2ccccc2n1)CN1CCCCC1
Show InChI InChI=1S/C21H25N3O/c1-3-12-23(13-4-1)14-6-16-25-19-10-8-18(9-11-19)20-17-24-15-5-2-7-21(24)22-20/h2,5,7-11,15,17H,1,3-4,6,12-14,16H2
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 6n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127831
PNG
(2-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-pyrazolo[1...)
Show SMILES C(COc1ccc(cc1)-c1cc2ccccn2n1)CN1CCCCC1
Show InChI InChI=1S/C21H25N3O/c1-3-12-23(13-4-1)14-6-16-25-20-10-8-18(9-11-20)21-17-19-7-2-5-15-24(19)22-21/h2,5,7-11,15,17H,1,3-4,6,12-14,16H2
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 11n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127838
PNG
(1-Methyl-2-[2-methyl-4-(3-piperidin-1-yl-propoxy)-...)
Show SMILES Cc1c(cn2ccccc12)-c1ccc(OCCCN2CCCCC2)cc1C
Show InChI InChI=1S/C24H30N2O/c1-19-17-21(27-16-8-14-25-12-5-3-6-13-25)10-11-22(19)23-18-26-15-7-4-9-24(26)20(23)2/h4,7,9-11,15,17-18H,3,5-6,8,12-14,16H2,1-2H3
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 11n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127841
PNG
(2-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-indolizine...)
Show SMILES C(COc1ccc(cc1)-c1cc2ccccn2c1)CN1CCCCC1
Show InChI InChI=1S/C22H26N2O/c1-3-12-23(13-4-1)14-6-16-25-22-10-8-19(9-11-22)20-17-21-7-2-5-15-24(21)18-20/h2,5,7-11,15,17-18H,1,3-4,6,12-14,16H2
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 13n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127839
PNG
(1-Methanesulfonyl-2-[4-(3-piperidin-1-yl-propoxy)-...)
Show SMILES CS(=O)(=O)n1c(cc2ccccc12)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H28N2O3S/c1-29(26,27)25-22-9-4-3-8-20(22)18-23(25)19-10-12-21(13-11-19)28-17-7-16-24-14-5-2-6-15-24/h3-4,8-13,18H,2,5-7,14-17H2,1H3
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 16n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127834
PNG
(1-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES Cc1c(cn2ccccc12)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H28N2O/c1-19-22(18-25-16-6-3-8-23(19)25)20-9-11-21(12-10-20)26-17-7-15-24-13-4-2-5-14-24/h3,6,8-12,16,18H,2,4-5,7,13-15,17H2,1H3
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 16n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127840
PNG
(1-Ethyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-in...)
Show SMILES CCc1c(cn2ccccc12)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C24H30N2O/c1-2-22-23(19-26-17-7-4-9-24(22)26)20-10-12-21(13-11-20)27-18-8-16-25-14-5-3-6-15-25/h4,7,9-13,17,19H,2-3,5-6,8,14-16,18H2,1H3
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 19n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127830
PNG
(6-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES Cc1ccc2cc(cn2c1)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H28N2O/c1-19-6-9-22-16-21(18-25(22)17-19)20-7-10-23(11-8-20)26-15-5-14-24-12-3-2-4-13-24/h6-11,16-18H,2-5,12-15H2,1H3
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 28n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127835
PNG
(1-Phenethyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl...)
Show SMILES C(COc1ccc(cc1)-c1cn2ccccc2c1CCc1ccccc1)CN1CCCCC1
Show InChI InChI=1S/C30H34N2O/c1-3-10-25(11-4-1)13-18-28-29(24-32-22-8-5-12-30(28)32)26-14-16-27(17-15-26)33-23-9-21-31-19-6-2-7-20-31/h1,3-5,8,10-12,14-17,22,24H,2,6-7,9,13,18-21,23H2
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 37n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127833
PNG
(8-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES Cc1cccn2cc(cc12)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H28N2O/c1-19-7-5-15-25-18-21(17-23(19)25)20-8-10-22(11-9-20)26-16-6-14-24-12-3-2-4-13-24/h5,7-11,15,17-18H,2-4,6,12-14,16H2,1H3
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 40n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127847
PNG
(1-Phenyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES C(COc1ccc(cc1)-c1cn2ccccc2c1-c1ccccc1)CN1CCCCC1
Show InChI InChI=1S/C28H30N2O/c1-3-10-24(11-4-1)28-26(22-30-20-8-5-12-27(28)30)23-13-15-25(16-14-23)31-21-9-19-29-17-6-2-7-18-29/h1,3-5,8,10-16,20,22H,2,6-7,9,17-19,21H2
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 40n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127846
PNG
(7-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES Cc1ccn2cc(cc2c1)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H28N2O/c1-19-10-14-25-18-21(17-22(25)16-19)20-6-8-23(9-7-20)26-15-5-13-24-11-3-2-4-12-24/h6-10,14,16-18H,2-5,11-13,15H2,1H3
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 40n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127843
PNG
(5-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES Cc1cccc2cc(cn12)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H28N2O/c1-19-7-5-8-22-17-21(18-25(19)22)20-9-11-23(12-10-20)26-16-6-15-24-13-3-2-4-14-24/h5,7-12,17-18H,2-4,6,13-16H2,1H3
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 46n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127837
PNG
(2-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-1H-indole ...)
Show SMILES C(COc1ccc(cc1)-c1cc2ccccc2[nH]1)CN1CCCCC1
Show InChI InChI=1S/C22H26N2O/c1-4-13-24(14-5-1)15-6-16-25-20-11-9-18(10-12-20)22-17-19-7-2-3-8-21(19)23-22/h2-3,7-12,17,23H,1,4-6,13-16H2
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 47n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127845
PNG
(2-[2-Methyl-4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)
Show SMILES Cc1cc(OCCCN2CCCCC2)ccc1-c1cc2ccccn2c1
Show InChI InChI=1S/C23H28N2O/c1-19-16-22(26-15-7-13-24-11-4-2-5-12-24)9-10-23(19)20-17-21-8-3-6-14-25(21)18-20/h3,6,8-10,14,16-18H,2,4-5,7,11-13,15H2,1H3
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 152n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127836
PNG
(2-[2-(3-Piperidin-1-yl-propoxy)-phenyl]-indolizine...)
Show SMILES C(COc1ccccc1-c1cc2ccccn2c1)CN1CCCCC1
Show InChI InChI=1S/C22H26N2O/c1-5-12-23(13-6-1)14-8-16-25-22-11-3-2-10-21(22)19-17-20-9-4-7-15-24(20)18-19/h2-4,7,9-11,15,17-18H,1,5-6,8,12-14,16H2
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 236n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50127842
PNG
(2-[3-(3-Piperidin-1-yl-propoxy)-phenyl]-indolizine...)
Show SMILES C(COc1cccc(c1)-c1cc2ccccn2c1)CN1CCCCC1
Show InChI InChI=1S/C22H26N2O/c1-3-11-23(12-4-1)13-7-15-25-22-10-6-8-19(17-22)20-16-21-9-2-5-14-24(21)18-20/h2,5-6,8-10,14,16-18H,1,3-4,7,11-13,15H2
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 308n/an/an/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development L. L. C.

Curated by ChEMBL


Assay Description
Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand

Bioorg Med Chem Lett 13: 1767-70 (2003)


BindingDB Entry DOI: 10.7270/Q21835V3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163251
PNG
(2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(O)cc2)cc1
Show InChI InChI=1S/C20H15N3O2S/c21-19(25)13-3-10-17-18(11-13)23-20(22-17)12-1-6-15(7-2-12)26-16-8-4-14(24)5-9-16/h1-11,24H,(H2,21,25)(H,22,23)
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n/an/a 2n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Chk2

Bioorg Med Chem Lett 17: 6467-71 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.098
BindingDB Entry DOI: 10.7270/Q2KP81XB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163251
PNG
(2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(O)cc2)cc1
Show InChI InChI=1S/C20H15N3O2S/c21-19(25)13-3-10-17-18(11-13)23-20(22-17)12-1-6-15(7-2-12)26-16-8-4-14(24)5-9-16/h1-11,24H,(H2,21,25)(H,22,23)
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n/an/a 2.30n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163246
PNG
(2-[4-(3,4-Dichloro-phenylsulfamoyl)-phenyl]-1H-ben...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N4O3S/c21-15-7-4-13(10-16(15)22)26-30(28,29)14-5-1-11(2-6-14)20-24-17-8-3-12(19(23)27)9-18(17)25-20/h1-10,26H,(H2,23,27)(H,24,25)
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n/an/a 3.40n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24206
PNG
(2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1,3-benzoxazo...)
Show SMILES C(CN1CCCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1
Show InChI InChI=1S/C21H24N2O3/c1-2-6-14-23(13-5-1)15-16-24-17-9-11-18(12-10-17)25-21-22-19-7-3-4-8-20(19)26-21/h3-4,7-12H,1-2,5-6,13-16H2
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n/an/a 4n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163259
PNG
(2-[4-(3-Chloro-4-methyl-phenoxy)-phenyl]-1H-benzoi...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)cc1Cl
Show InChI InChI=1S/C21H16ClN3O2/c1-12-2-6-16(11-17(12)22)27-15-7-3-13(4-8-15)21-24-18-9-5-14(20(23)26)10-19(18)25-21/h2-11H,1H3,(H2,23,26)(H,24,25)
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n/an/a 4.40n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163254
PNG
(2-[4-(4-Chloro-3-trifluoromethyl-phenoxy)-phenyl]-...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H13ClF3N3O2/c22-16-7-6-14(10-15(16)21(23,24)25)30-13-4-1-11(2-5-13)20-27-17-8-3-12(19(26)29)9-18(17)28-20/h1-10H,(H2,26,29)(H,27,28)
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n/an/a 4.5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163266
PNG
(2-[4-(3,4-Dichloro-phenoxy)-phenyl]-1H-benzoimidaz...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C20H13Cl2N3O2/c21-15-7-6-14(10-16(15)22)27-13-4-1-11(2-5-13)20-24-17-8-3-12(19(23)26)9-18(17)25-20/h1-10H,(H2,23,26)(H,24,25)
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n/an/a 5.5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24216
PNG
(1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}-4-p...)
Show SMILES OC1(CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1)c1ccccc1
Show InChI InChI=1S/C26H26N2O4/c29-26(20-6-2-1-3-7-20)14-16-28(17-15-26)18-19-30-21-10-12-22(13-11-21)31-25-27-23-8-4-5-9-24(23)32-25/h1-13,29H,14-19H2
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n/an/a 6n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163264
PNG
(2-[4-(4-Chloro-benzenesulfonyl)-phenyl]-1H-benzoim...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H14ClN3O3S/c21-14-4-8-16(9-5-14)28(26,27)15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
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n/an/a 6.60n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24199
PNG
(2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1,3-benzo...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1
Show InChI InChI=1S/C19H20N2O3/c1-2-6-18-17(5-1)20-19(24-18)23-16-9-7-15(8-10-16)22-14-13-21-11-3-4-12-21/h1-2,5-10H,3-4,11-14H2
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n/an/a 7n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24224
PNG
(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...)
Show SMILES OC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C20H22N2O2S/c23-16-10-13-22(14-11-16)12-9-15-5-7-17(8-6-15)24-20-21-18-3-1-2-4-19(18)25-20/h1-8,16,23H,9-14H2
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n/an/a 8n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24238
PNG
(Benzthiazole compound, 33p | N-(1-{[4-(1,3-benzoth...)
Show SMILES OCC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C21H23N3O3S/c25-14-20(26)22-16-9-11-24(12-10-16)13-15-5-7-17(8-6-15)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,16,25H,9-14H2,(H,22,26)
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n/an/a 8n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163255
PNG
(2-[4-(4-Chloro-phenylsulfanyl)-phenyl]-1H-benzoimi...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C20H14ClN3OS/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
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n/an/a 8.20n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24212
PNG
(1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}pipe...)
Show SMILES OC1CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1
Show InChI InChI=1S/C20H22N2O4/c23-15-9-11-22(12-10-15)13-14-24-16-5-7-17(8-6-16)25-20-21-18-3-1-2-4-19(18)26-20/h1-8,15,23H,9-14H2
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n/an/a 9n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163282
PNG
(2-[4-(4-Chloro-3-hydroxy-phenoxy)-phenyl]-1H-benzo...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)c(O)c2)cc1
Show InChI InChI=1S/C20H14ClN3O3/c21-15-7-6-14(10-18(15)25)27-13-4-1-11(2-5-13)20-23-16-8-3-12(19(22)26)9-17(16)24-20/h1-10,25H,(H2,22,26)(H,23,24)
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n/an/a 9.80n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24235
PNG
(3-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}p...)
Show SMILES O=C1OCCN1C1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C22H23N3O3S/c26-22-25(13-14-27-22)17-9-11-24(12-10-17)15-16-5-7-18(8-6-16)28-21-23-19-3-1-2-4-20(19)29-21/h1-8,17H,9-15H2
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n/an/a 10n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24203
PNG
(2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzox...)
Show SMILES C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1
Show InChI InChI=1S/C20H22N2O3/c1-4-12-22(13-5-1)14-15-23-16-8-10-17(11-9-16)24-20-21-18-6-2-3-7-19(18)25-20/h2-3,6-11H,1,4-5,12-15H2
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n/an/a 11n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24222
PNG
(3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)
Show SMILES O=C1OCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C23H25N3O4S/c27-23-26(14-16-29-23)17-9-11-25(12-10-17)13-15-28-18-5-7-19(8-6-18)30-22-24-20-3-1-2-4-21(20)31-22/h1-8,17H,9-16H2
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n/an/a 11n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24239
PNG
(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}pipe...)
Show SMILES OC(=O)C1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C20H20N2O3S/c23-19(24)15-9-11-22(12-10-15)13-14-5-7-16(8-6-14)25-20-21-17-3-1-2-4-18(17)26-20/h1-8,15H,9-13H2,(H,23,24)
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n/an/a 11n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24234
PNG
(1-(1-{[4-(1,3-benzothiazol-2-yloxy)phenyl]methyl}p...)
Show SMILES O=C1CCCN1C1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C23H25N3O2S/c27-22-6-3-13-26(22)18-11-14-25(15-12-18)16-17-7-9-19(10-8-17)28-23-24-20-4-1-2-5-21(20)29-23/h1-2,4-5,7-10,18H,3,6,11-16H2
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n/an/a 12n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24236
PNG
(Benzthiazole compound, 33n | N-(1-{[4-(1,3-benzoth...)
Show SMILES CC(=O)NC1CCN(Cc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C21H23N3O2S/c1-15(25)22-17-10-12-24(13-11-17)14-16-6-8-18(9-7-16)26-21-23-19-4-2-3-5-20(19)27-21/h2-9,17H,10-14H2,1H3,(H,22,25)
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n/an/a 12n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163250
PNG
(2-[4-(3,4-Dimethyl-phenoxy)-phenyl]-1H-benzoimidaz...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)cc1C
Show InChI InChI=1S/C22H19N3O2/c1-13-3-7-18(11-14(13)2)27-17-8-4-15(5-9-17)22-24-19-10-6-16(21(23)26)12-20(19)25-22/h3-12H,1-2H3,(H2,23,26)(H,24,25)
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n/an/a 12n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163270
PNG
(2-[4-(2-Fluoro-5-trifluoromethyl-phenoxy)-phenyl]-...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H13F4N3O2/c22-15-7-4-13(21(23,24)25)10-18(15)30-14-5-1-11(2-6-14)20-27-16-8-3-12(19(26)29)9-17(16)28-20/h1-10H,(H2,26,29)(H,27,28)
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n/an/a 12n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163278
PNG
(2-[4-(Naphthalen-2-yloxy)-phenyl]-1H-benzoimidazol...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C24H17N3O2/c25-23(28)18-8-12-21-22(14-18)27-24(26-21)16-6-9-19(10-7-16)29-20-11-5-15-3-1-2-4-17(15)13-20/h1-14H,(H2,25,28)(H,26,27)
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n/an/a 12n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24215
PNG
((1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}p...)
Show SMILES OCC1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C21H24N2O3S/c24-15-16-9-11-23(12-10-16)13-14-25-17-5-7-18(8-6-17)26-21-22-19-3-1-2-4-20(19)27-21/h1-8,16,24H,9-15H2
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n/an/a 13n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24218
PNG
(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...)
Show SMILES NC(=O)C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C21H23N3O3S/c22-20(25)15-9-11-24(12-10-15)13-14-26-16-5-7-17(8-6-16)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,15H,9-14H2,(H2,22,25)
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n/an/a 13n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24227
PNG
(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}...)
Show SMILES O=C1CCCN1C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1
Show InChI InChI=1S/C24H27N3O2S/c28-23-6-3-14-27(23)19-12-16-26(17-13-19)15-11-18-7-9-20(10-8-18)29-24-25-21-4-1-2-5-22(21)30-24/h1-2,4-5,7-10,19H,3,6,11-17H2
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n/an/a 13n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50163269
PNG
(2-[4-(4-Chloro-benzenesulfinyl)-phenyl]-1H-benzoim...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)S(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H14ClN3O2S/c21-14-4-8-16(9-5-14)27(26)15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
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n/an/a 13n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of recombinant human Chk2 kinase

J Med Chem 48: 1873-85 (2005)


Article DOI: 10.1021/jm0495935
BindingDB Entry DOI: 10.7270/Q2FQ9W4V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk2


(Homo sapiens (Human))		BDBM50225014
PNG
(2-(4-((1-(4-chlorobenzyl)piperidin-3-yl)methoxy)ph...)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(OCC2CCCN(Cc3ccc(Cl)cc3)C2)cc1
Show InChI InChI=1S/C27H27ClN4O2/c28-22-8-3-18(4-9-22)15-32-13-1-2-19(16-32)17-34-23-10-5-20(6-11-23)27-30-24-12-7-21(26(29)33)14-25(24)31-27/h3-12,14,19H,1-2,13,15-17H2,(H2,29,33)(H,30,31)
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n/an/a 14n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Chk2

Bioorg Med Chem Lett 17: 6467-71 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.098
BindingDB Entry DOI: 10.7270/Q2KP81XB
More data for this
Ligand-Target Pair
Leukotriene A-4 hydrolase


(Homo sapiens (Human))		BDBM24201
PNG
(2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1,3-benzo...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C19H20N2O2S/c1-2-6-18-17(5-1)20-19(24-18)23-16-9-7-15(8-10-16)22-14-13-21-11-3-4-12-21/h1-2,5-10H,3-4,11-14H2
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n/an/a 14n/an/an/an/a7.422



Johnson & Johnson Pharmaceutical



Assay Description
Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...

J Med Chem 51: 4150-69 (2008)


Article DOI: 10.1021/jm701575k
BindingDB Entry DOI: 10.7270/Q2GB22CX
More data for this
Ligand-Target Pair
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