| Reaction Details |
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 | Report a problem with these data |
| Target | G-protein coupled receptor 6 |
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| Ligand | BDBM381944 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of cAMP Activity of GPR6 In Vitro Assay |
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| EC50 | 38700±n/a nM |
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| Citation |  Adams, ME; Brown, JW; Hitchcock, S; Hopkins, M; Kikuchi, S; Lam, B; Monenschein, H; Reichard, H; Sun, H Pyrazines as modulators of GPR6 US Patent US10000468 Publication Date 6/19/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| G-protein coupled receptor 6 |
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| Name: | G-protein coupled receptor 6 |
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| Synonyms: | G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6 |
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| Type: | Protein |
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| Mol. Mass.: | 37886.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46095 |
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| Residue: | 362 |
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| Sequence: | MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
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| BDBM381944 |
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| n/a |
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| Name | BDBM381944 |
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| Synonyms: | US10000468, Example 14 | US10273225, Example 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25F2N7O |
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| Mol. Mass. | 441.477 |
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| SMILES | CN(C)C(=O)c1nc(NC2CC2)c(nc1C#N)N1CCN(Cc2ccc(F)cc2F)CC1 |
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| Structure | 
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