| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen phosphorylase, muscle form |
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| Ligand | BDBM34110 |
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| Substrate/Competitor | BDBM23188 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 6.8±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 630±20 nM |
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| Citation |  Benltifa, M; Hayes, JM; Vidal, S; Gueyrard, D; Goekjian, PG; Praly, JP; Kizilis, G; Tiraidis, C; Alexacou, KM; Chrysina, ED; Zographos, SE; Leonidas, DD; Archontis, G; Oikonomakos, NG Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors. Bioorg Med Chem17:7368-80 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Glycogen phosphorylase, muscle form |
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| Name: | Glycogen phosphorylase, muscle form |
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| Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
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| Type: | Enzyme |
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| Mol. Mass.: | 97296.32 |
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| Organism: | Oryctolagus cuniculus (rabbit) |
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| Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
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| Residue: | 843 |
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| Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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| BDBM34110 |
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| BDBM23188 |
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| Name | BDBM34110 |
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| Synonyms: | glucopyranosylidene-spiro-isoxazoline, 4e |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19NO6 |
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| Mol. Mass. | 345.3466 |
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| SMILES | OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O |c:6| |
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| Structure | 
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