| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
|---|
| Ligand | BDBM34159 |
|---|
| Substrate/Competitor | BDBM21342 |
|---|
| Meas. Tech. | 5-HT6 Binding Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| Ki | 43±n/a nM |
|---|
| IC50 | 3000±n/a nM |
|---|
| Comments | 78% inhibition @ 100 nM. |
|---|
| Citation |  Alcalde, E; Mesquida, N; López-Pérez, S; Frigola, J; Mercè, R; Holenz, J; Pujol, M; Hernández, E Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts. Bioorg Med Chem17:7387-97 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 6 |
|---|
| Name: | 5-hydroxytryptamine receptor 6 |
|---|
| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46968.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P50406 |
|---|
| Residue: | 440 |
|---|
| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
|
|
|
|---|
| BDBM34159 |
|---|
| BDBM21342 |
|---|
| Name | BDBM34159 |
|---|
| Synonyms: | indenylsulfonamide, 47+48 | isomeric mixture (70% 5-indenyl, 30% 6-indenyl) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12ClN3O2S2 |
|---|
| Mol. Mass. | 365.858 |
|---|
| SMILES | CC1=Cc2cc(NS(=O)(=O)c3c(Cl)nc4sccn34)ccc2C1 |t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
