Reaction Details | |||
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Report a problem with these data | |||
Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM350851 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 0.890±n/a nM | ||
Citation | Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity US Patent US10004755 Publication Date 6/26/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM350851 | |||
n/a | |||
Name | BDBM350851 | ||
Synonyms: | UNC2123A | US10004755, Compound UNC2123A | US9795606, B10 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H28FN5 | ||
Mol. Mass. | 393.5003 | ||
SMILES | N[C@H]1CCC(CC1)n1cc(-c2ccc(F)cc2)c2cnc(NCCC3CC3)nc12 |r,wU:7.7,wD:1.0,(5.85,-7.2,;5.45,-5.71,;6.54,-4.62,;6.14,-3.13,;4.66,-2.73,;3.57,-3.82,;3.97,-5.31,;4.26,-1.25,;5.16,,;4.26,1.25,;4.66,2.73,;6.14,3.13,;6.54,4.62,;5.45,5.71,;5.85,7.2,;3.97,5.31,;3.57,3.82,;2.79,.77,;1.46,1.54,;.13,.77,;.13,-.77,;-1.21,-1.54,;-2.54,-.77,;-3.88,-1.54,;-5.21,-.77,;-6.54,,;-6.54,-1.54,;1.46,-1.54,;2.79,-.77,)| | ||
Structure |